Edith Meiser graduated from Vassar College and became an actress. She made her stage debut in 1923 and appeared in more than 20 Broadway shows, including three runs in the Theater Guild's annual "Garrick Gaeties" musical revue that spoofed popular shows of the day. She also acted in films, on television, and on the radio. Her passion from childhood was Sherlock Holmes stories. In the 1930s, she began lobbying the radio networks to air a series based on the Holmes stories, and succeeded after winning over the sponsors. The adaptations and original stories she wrote and produced were praised by Sir Arthur Conan Doyle's family for their faithfulness to the original characters and Victorian settings.
Sherlock Holmes owes much of his continuing popularity with the public to her efforts. She was named an honorary member of the Baker Street Irregulars, the Sherlock Holmes fan society. She also wrote mystery novels and a play called The Wooden O.