Best known for his comedic work in the 1980s and 1990s with fellow UK actor Hugh Laurie as half of the comedy team Fry & Laurie, and as Jeeves in the UK television series adaptation of P G Wodehouse's Jeeves & Wooster books. Has also portrayed Oscar Wilde in the UK film Wilde. Has also worked with Ade Edmonson and Rick Mayall, often guest-starring in their own television series', The Young Ones and Filthy, Rich & Catflap, with comedic partner Laurie.
Has battled bipolar disorder. Is a self-described technology fiend.
Currently spends a lot of time on his iPhone updating his Twitter microblog.