Dr. Edward R.B. McCabe began his research career at the age of 15 in the pediatric research laboratory at the University of Maryland School of Medicine. He graduated from The Johns Hopkins University, and earned his MD and PhD degrees from the University of Southern California. He completed his pediatric residency at the University of Minnesota. Today he is senior vice president and chief medical officer of the March of Dimes Foundation. He has served as Executive Director of the Linda Crnic Institute for Down Syndrome, the Anna and John J. Sie Endowed Chair in Down Syndrome Research and Clinical Care, and a professor in the Department of Pediatrics at the University of Colorado School of Medicine from 2010-2012. Prior to his appointment at Colorado, he was at the UCLA as executive chairman of the Department of Pediatrics and physician-in-chief of the Mattel Children’s Hospital. He also held the Mattel Endowed Chair of Pediatrics and was professor of genetics as well as professor of bioengineering. He founded and served as co-director of the UCLA Center for Society and Genetics and established the first program in nano-pediatrics. With his wife, Linda McCabe, PhD, he wrote How to Succeed in Academics and DNA: Promise and Peril (2010), to support the courses they taught at UCLA.