Evelyn E. Smith was born in New York City. During the 1950s, an era when women rarely appeared in science fiction magazines, she regularly published short stories and novelettes in Galaxy Science Fiction, Fantastic Universe, and The Magazine of Fantasy & Science Fiction, among others. She also wrote science fiction novels, beginning with The Perfect Planet (1962), often focused on gender identity. However, she is probably best known today for her series of mystery novels about Miss Melville, a middle-aged socialite-turned-assassin, who made her debut in Miss Melville Regrets (1986). Under the pseudonym Delphine C. Lyons, she also published at least five gothic romance novels such as Flower of Evil (1965) and the nonfiction work Everyday Witchcraft (1972). Her short story "At Last I've Found You" was adapted into an opera by Seymour Barab in 1984. Two volumes of her collected stories were published posthumously as Evelyn E. Smith Resurrected: Selected Stories of Evelyn E Smith (2010) and The Best of Evelyn E. Smith: The Two Suns of Morcali and Other Stories (2012). Her work appears in numerous anthologies.