Anne Neville (c. 1455-1485) was the younger daughter of Richard Neville, Earl of Warwick -- nicknamed "the Kingmaker" -- and was used as a political pawn in the Wars of the Roses. There is no indication that she was anything like the Lady Anne of Shakespeare's play Richard III. In 1470, when Warwick was trying to supplant King Edward IV, he married Anne to Prince Edward, the son of King Henry VI. Edward died at the Battle of Tewkesbury, and Anne then became the center of a contest between King Edward's brothers George of Clarence and Richard of Gloucester, which did not end when Richard married her. It has been said that they were childhood friends, since Richard was educated in Warwick's household, but again, there is little evidence of this. They had one son, Edward of Middleham, born around 1475, who died at age 10. Anne died, probably of tuberculosis, in 1485. The evidence against the rumor that Richard poisoned her is overwhelming, and his grief for her seems to have been genuine.