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A wide variety of disciplines are embracing tablet PCs and similar pen-based devices as tools for the radical enhancement of teaching and learning. Deployments of tablet PCs have spanned the K-12, undergraduate, and graduate levels and have dealt with an amazingly diverse range of subject areas including nursing, veterinary science, geology, ethno-musicology, anthropology, landscape architecture, writing, mathematics, computer science, Japanese language, physics, engineering, art, economics, as well as others. Despite the diversity of content areas, many deployments have been similar in terms of the passion they have generated among students and teachers. This work, stemming from the Fifth Workshop on the Impact of Pen-Based Technology on Education (WIPTE), will help the reader appreciate this passion. Each chapter consists of a refereed paper contributed by an author with experience deploying tablet PCs to support teaching and learning. Each author's experiences are presented along with the results of an evaluation of the effectiveness of the approach.