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The author argues that traditional methods of international relations theory, such as realism and liberalism, are not good predictive tools in an effort to forecast the behaviors of state and non-state actors. The complex web of religious ideologies, globally connected information technologies, and the interdependence of a globalized economy are some examples of driving forces that confound traditional international relations theory. The author reviews the strategic cultures of the United States, China, Iran, North Korea, and al-Qaeda in order to develop actionable policy guidelines.