In 1578, vampire Ileana Vladislava flees Transylvania in the midst of a vampire witch hunt and reestablishes herself in Newcastle upon Tyne, a city in Tyne and Wear, England. Hundreds of years later, in 2017, we find Ileana living out a lonely existence in Wightwick Hall, a castle within the Jesmond Dene woodland valley. When Ileana sees the young and beautiful Myrna Ivester at a public library, there is something about her that sets her apart from anyone else. She decides to take a risk and transform Myrna into a vampire believing it is her destiny. With the impending threat against the vampires by Claymor, a vampire hunter in the form of a grudge bearing werewolf, the war between good and evil finds a new battlefield in Newcastle upon Tyne.