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Soledad Numeros Primos (original 2008; edition 2009)
The Solitude of Prime Numbers by Paolo Giordano (2008)
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Alice and Mattia are both misfits who seem destined to be alone. Haunted by childhood tragedies that mark their lives, they cannot reach out to anyone else. When Alice and Mattia meet as teenagers, they recognize in each other a kindred, damaged spirit. When Mattia accepts a research position that takes him thousands of miles away, the two are forced to separate. Then a chance occurrence reunites them, forcing a lifetime of concealed emotion to the surface.
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