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Y: The Last Man: Unmanned by Brian K. Vaughan
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In the summer of 2002, a plague of unknown origin destroyed every last sperm, fetus, and fully developed mammal with a Y chromosome-with the apparent exception of one young man and his male pet. This "gendercide" instantaneously exterminated 48% of the global population, or approximately 2.9 billion men. Now, aided by the mysterious Agent 355, the last human male Yorick Brown must contend with dangerous extremists, a hoped-for reunion with a girlfriend on the other side of the globe, and the search for exactly why he's the only man to survive.
(summary from another edition)
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