Henri-Pierre Roché was born in Paris, and studied art at the Académie Julian. He became a diplomat, journalist, art collector and dealer and was a friend of many young artists such as Max Jacob and Pablo Picasso. Gertrude Stein described him in her book The Autobiography of Alice B. Toklas. He was also a close friend of Marcel Duchamp, and went with him to New York City in 1916. There, he and Duchamp teamed up with Beatrice Wood (who was the lover of both men) to found The Blind Man, an avant-garde magazine that was followed the Dada art movement.
Late in his life, he wrote and published two successful novels, Jules and Jim (1952) and Les deux anglaises et le continent (Two English Girls, 1956). Both works were adapted into films by French director François Truffaut.