Louisa Siefert was born to a French Protestant family in Lyon, and received a religious education. Her parents were Henry Siefert, vice-consul to Portugal, and his wife Adele-Adrienne Belz. Louisa met Charles Asselineau, a writer and friend of Baudelaire, in 1863, and though him got to know many other writers such as Victor Hugo, Edgar Quinet, Charles Augustin Sainte-Beuve, and Jules Michelet. In 1868, she published her first collection of poems, Rayons perdus, to great acclaim. She published a novel, Méline (1875), and several other volumes of poetry before dying at age 32 in 1877 in Pau, where she was being treated for tuberculosis.