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Whether Translation Studies really matters is an important and challenging question which practitioners of translation and interpreting raise repeatedly. TS scholars, many of whom are translators and interpreters themselves, are not indifferent to it either. The twenty papers of this thematic volume, contributed by authors from various parts of Europe, from Brazil and from Israel, address it in a positive spirit. Some do so through direct critical reflection and analysis, arguing in particular that the engagement of TS with society should be strengthened so that the latter could benefit more from the former. Others illustrate the relevance and contribution of TS to society and to other disciplines from various angles. Topics broached include the cultural mediation role of translators, issues in literary translation, knowledge as intellectual capital, globalization through English and risks associated with it, bridging languages, mass media, corpora, training, the use of modern technology, interdisciplinarity with psycholinguistics and neurophysiology.