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Click Chemistry in Glycoscience: New Developments and Strategies

by Zbigniew J. Witczak

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Lays the foundation for new methods and applications ofcarbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps ResearchInstitute in 2001, click chemistry mimics nature, givingresearchers the tools needed to generate new substances quickly andreliably by joining small units together. With contributions frommore than thirty pioneering researchers in the field, this textexplores the many promising applications of click chemistry inglycoscience. Readers will learn both the basic concepts ofcarbohydrate click chemistry as well as its many biomedicalapplications, including synthetic antigens, analogs of cell-surfacereceptors, immobilized enzymes, targeted drug delivery systems, andmultivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range ofmethodologies and strategies that have emerged from this rapidlyevolving field. Each chapter describes new approaches, ideas,consequences, and applications resulting from the introduction ofclick processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recentfindings published in the literature. Diagrams and figuresthroughout the book enable readers to more easily grasp complexconcepts and reaction processes. At the end of each chapter,references lead to the primary literature for further investigationof individual topics. The application of click chemistry to carbohydrates hastremendous implications for research. With this book as theirguide, researchers have a solid foundation from which they candevelop new methods and applications of carbohydrate clickchemistry, including new carbohydrate-based therapeutics.… (more)
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Lays the foundation for new methods and applications ofcarbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps ResearchInstitute in 2001, click chemistry mimics nature, givingresearchers the tools needed to generate new substances quickly andreliably by joining small units together. With contributions frommore than thirty pioneering researchers in the field, this textexplores the many promising applications of click chemistry inglycoscience. Readers will learn both the basic concepts ofcarbohydrate click chemistry as well as its many biomedicalapplications, including synthetic antigens, analogs of cell-surfacereceptors, immobilized enzymes, targeted drug delivery systems, andmultivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range ofmethodologies and strategies that have emerged from this rapidlyevolving field. Each chapter describes new approaches, ideas,consequences, and applications resulting from the introduction ofclick processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recentfindings published in the literature. Diagrams and figuresthroughout the book enable readers to more easily grasp complexconcepts and reaction processes. At the end of each chapter,references lead to the primary literature for further investigationof individual topics. The application of click chemistry to carbohydrates hastremendous implications for research. With this book as theirguide, researchers have a solid foundation from which they candevelop new methods and applications of carbohydrate clickchemistry, including new carbohydrate-based therapeutics.

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