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This is an advocacy of our mission statement to create a Learning Health System (LHS) that will enable data to be rapidly mobilized, continuously analyzed"and the results subsequently shared"to improve health care quality, empower public health and biomedical research, and enable clinicians and patients to collaboratively make better-informed health decisions using scientific data concerning what works best in every disease. The book builds upon, and is a natural progression from, the work we have done together over the years to generate strong bipartisan support for the concept and vision of a Learning Health System.