Cherry Ames takes a break from city nursing, and joins her friend Bertha Larsen in Heartbreak Hollow. This rural setting has wonderful people who haven't been exposed to a lot of modern medicine, so Cherry and Bertha are needed desperately. But things start to go awry when an entire batch of wool is ruined and a hog is poisoned. It reignites a feud between the Clarkes and the Smiths, prohibits two lovebirds from marrying, and sparks ferver in the devil interfearing in their lives. Cherry must use all her resources to save the town from whooping cough and a "devil in disguise".