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The Susquehana River is the longest river in the eastern United States, running 444 miles from its headwaters in the Appalachian Mountains of New York to its outlet in Chesapeake Bay. Its storied history includes the early native populations of Susquehannock and Iroquois peoples, the key roles it played in the Revolutionary and Civil Wars, and environmental degradation brought on the by industrialization in the 19th century.