Dr. Mark Sloan's day at the office takes a turn for the worse when he looks out the window and sees a woman jump from the ledge of a building. Miraculously he is able to save her life, but she remains in a coma. Tormented by nightmares about the event, Mark investigates the causes behind the woman's attempted suicide, which leads him to a U.S. marshal's relentless manhunt for a cop killer. And if Mark doesn't tread lightly, he may find himself the next target....