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When the volcano Popocatepetl erupts, a massive, reptilian monster crawls out of the caldera and begins attacking Mexico City. Unable to stop it, the military calls on Elena Baz, a disabled physicist who consults with the Mexican Army. Dr. Baz gathers a team of the greatest scientific minds, searching for a way to bring the behemoth down. But as the kaiju leaves a swath of destruction across Central Mexico, other volcanoes grow more and more active. Now the nation's only hope lies with Alfonso Becerra, an indigenous anthropologist with radical fringe ideas. Elena and Alfonso will have to overcome their personal traumas and long-standing feud in order to work together. For only a blend of science and myth can save Mexico from the ancient Lords of the Earth.