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To all the world, Damien Thorn (Sam Neill) is a philanthropist who has helped rescue the world from a recession. But when he becomes the U.S. Ambassador to England, Damien fulfills a horrifying biblical prophecy. He also faces his own potential demise when an astronomical event brings about the second coming of Christ. Determined to thwart his holy arch-nemesis, as well as a group of priests intent on killing him, Damien begins his most destructive rampage yet.