The decisions that people living with HIV and AIDS (often referred to as PHAs or PWAs) must make about treating the disease can often seem overwhelmingly difficult. In this guide, we hope to provide the latest on what is currently known about the various aspects of treatment, as well as a bit of skepticism about anyone claiming to have definitive answers on this topic. We don’t know it all, but we will try to tell you what is known and, sometimes more importantly, what is not known about infection with the Human Immunodeficiency Virus (HIV) and how to treat it.