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This thoroughly revised and expanded new edition presents the current state of knowledge of the diverse applications of calcium antagonists and makes recommendations about their appropriate use. New sections have been added on Clinical Pharmacology and Metabolic Effects. Sixteen new chapters have been added on such topics as Pharmacogenetics of Hypertension: Using Gene Markers to Infer Pathogenesis and Guide Therapy, New Pharmacologic Directions for Calcium Channel Blockers, Calcium Channel Blocker Use in End-Stage Renal Disease: Pharmacokinetics and Pharmacodynamics, and many others. Significantly expanded from previous edition with 16 new chapters on hot topics A comprehensive reexamination of the safety of calcium antagonists in light of many newly reported clinical trials Elucidates the evolving role of calcium antagonists in the antihypertensive armamentarium, especially in the patient with diabetes Explores beneficial effects of calcium antagonists in attenuating atherosclerosis in the context of newly reported clinical trials, including ELSA. Written by world-renowned experts in the field Emphasizes evidence-based studies New chapters have been added on such topics as Pharmacogenetics of Hypertension: Using Gene Markers to Infer Pathogenesis and Guide Therapy, New Pharmacologic Directions for Calcium Channel Blockers, Calcium Channel Blocker Use in End-Stage Renal Disease: Pharmacokinetics and Pharmacodynamics.