Let's not forget the dogs, please...

The Curious Incident of the Dog in the Nightime by Mark Haddon
To Say Nothing of the Dog by Connie Willis
The Hound of the Baskervilles by Arthur Conan Doyle
Lirael by Garth Nix (stars the Disreputable Dog)
Three Men in a Boat by Jerome K. Jerome

Apologizing to Dogs by Joe Coomer
The Yellow Dog by Georges Simenon
Black Dog by Stephen Booth
The Hound of Death by Agatha Christie
Black Hounds of Death by Robert E. Howard

And, a favorite from my early childhood:
The Detective of London by Robert Kraus and Bruce Kraus, illustrated by Robert Byrd

Sorry--I can't get touchstones to work on some of these!

Deerskin (main character's dog plays an important role in the story)

Rowan (kids' book about a child getting a new pet dog)

A Night in the Lonesome October (narrated a watchdog named Snuff)

Terrier

Travels With Charley (the only Steinbeck I actually like - nonfiction memoir about traveling across America with his dog)

A Wizard Alone (Kit's dog, Ponch, is in all the books in this series, but he plays a more important role starting in this one.)

Dog and Duck, by Arthur Machen
The dogs bark; public people and private places, by Truman Capote
A Dog's Ransom, by Patricia Highsmith
Wish You Were Here, by Rita Mae Brown and Sneaky Pie Brown (and all the other books in this series)
Travels with Lizbeth, by Lars Eighner

The Plague Dogs - Richard Adams

The Dogs of War - Frederick Forsyth

Nop's Trials - Donald McCaig (about Border Collies)

The Dogs of God - P.Benedict

The One Hundred and One Dalmatians - Dodie Smith..can't believe I'm first with this one!

Lad, A Dog by Albert Payson Terhune (Can't believe I'm the first with this, if the touchstones don't take too long to load.)
The Old Dog Barks Backwards by Ogden Nash
Watchers by Dean R. Koontz (Great dog in this one.)
Man Meets Dog by Konrad Lorenz
Gone to the Dogs by Susan Conant

The Dogs of Babel
Don't Let's Go to the Dogs Tonight
Call of the Wild
Last Days of Dogtown
Lady and the Tramp

Antiques Roadkill by Barbara Allan (series featuring a blind dog)
Living a Dog's Life by Cindy Adams
Murder Can Depress Your Dachshund by Selma Eichler
Travels with Macy by Bruce Fogle
Because of Winn-Dixie by Kate DiCamillo

Old Yeller by Fred Gipson
Big Red by Jim Kjelgaard
Murder on the Iditarod Trail by Sue Henry
James Herriot's Dog Stories by James Herriot
Sick Puppy: a novel by Carl Hiaasen

Beautiful Joe by Marshall Saunders
White Fang by Jack London
Lassie, Come home by Eric Knight
The Dog in the Tapestry Garden by Dorothy Lathrop

and Toto,too...
The Wonderful Wizard of Oz by L. Frank Baum

Can you tell what I liked to read as a kid?

Outlaw Red by Jim Kjelgaard
The Critter and other Dogs by Albert Payson Terhune
The Black Spaniel Mystery by Betty Cavanna
Hotel For Dogs by Lois Duncan
Shiloh by Phyllis Reynolds Naylor

...and the rest of the canine family
My Dog Tulip
I am Charlotte Simmons by Tom Wolfe
A Man in Full by Tom Wolfe
Foxes Book of Martyrs
St. Francis and the Wolf

oh well, if we're including them:

The Book of Atrix Wolfe by Patricia A. McKillip
The Day of the Jackal by Frederick Forsyth
9tailfox by Jon Courtenay Grimwood*
Fantastic Mr Fox by Roald Dahl

and, because I missed it the first time round, and it's an old favourite

Sirius, by Olaf Stapledon

* touchstone doesn't seem to like that one!

Man Bites Dog by Adam Ford
Dog Day Afternoon by Patrick Mann
Emma and I by Sheila Hocken
The Dog Whisperer by Paul Owens
Walter. the Farting Dog by William Kotzwinkle - the property of my granddaughter but the book and the farting dog live at my place.

Rottweiler by Ruth Rendell
Dog Overboard! Adventures of Wishbone by Vivian Sarthre
The Incredible Journey by Sheila Burnford
Wolf to the Slaughter by Ruth Rendell
Isabella: She-Wolf of France, Queen of England by Alison Weir

Walking the Dog and Other Stories Bernard MacLaverty
Marley and Me: Life and Love with the World's Worst Dog John Grogan
I Had a Black Dog Matthew Johnstone
Black Dogs by Ian McEwan
Greyfriar's Bobby Eleanor Atkinson

Star Dog by Alice Lightner Hopf

Flight of the Old Dog by Dale Brown

Mr. Putter and Tabby Walk the Dog by Cynthia Rylant

Revenge of the Hound by Michael Hardwick

Benji by Allison Thomas

The Dog Who Bit a Policeman by Stuart Kaminsky
This Dog for Hire by Carol Lea Benjamin
The Case of the Howling Dog by Erle Stanley Gardner
The Hungry Dog by Frank Gruber
A Little Yellow Dog by Walter Mosley

Dogs in the plot but not the title:
The Idea of Perfection by Kate Grenville
The Sacred and Profane Love Machine by Iris Murdoch

Dogs in the title but not in the book (except as a sentence to diagram):
Sister Bernadette's Barking Dog by Kitty Burns Florey

“Dog books”
Dog Years by Mark Doty
Good Dog. Stay. by Anna Quindlen
Colter by Rick Bass (sorry but the touchstone's not working on this one)

P.S. - There are entire mystery series organized around dogs: those by Susan Conant (the human protagonist plus a malamute), Carol Lea Benjamin (a pit bull), Meslissa Cleary (a GSD), and Laurien Berenson (a standard poodle), to name a few. There's also one featuring a basset hound, but I forget the author's name. And have we forgotten the Jack Russell terrier who who used to solve crimes on PBS, Wishbone? I'm sure he was featured in many spin-off books.

Also, I know of other dog mysteries that may have been one-offs. For instance, Wolf at the Door by Ann Campbell.

Do we get credit for listing every title separately? I know some have already been mentioned . . .

Am I overthinking this????

The Diggingest Dog by Al Perkins
The Bravest Dog Ever: the True Story of Balto by Natalie Standiford
A Dog's Life by Peter Mayle
The Bookshop Dog by Cynthia Rylant
Dog Heaven by Cynthia Rylant

I've been on vacation and missed quite a few interesting topics:

Dogs that Have Known Me and Other Waggish Tales
The Stone Dogs by S. M. Stirling
Envoy to the Dog Star by Frederick L. Shaw
Bad Dog by Warren Murphy
The Dog Who Wouldn't Be by Farley Mowat

Welcome back.

Dog's Tale by Mark Twain
The Dog Who Knew Too Much by Carol Lea Benjamin
Hounded To Death by Lauren Berenson
Delilah Doolittle and the Motley Mutts by Patricia Gulliver
The House on Bloodhound Lane by Virginia Lanier

Four Past Midnight: The Sun Dog by Stephen King
Cujo by Stephen King
The Terra-Cotta Dog by Andrea Camilleri
Lassie Come-Home by Eric Knight
The Curious Incident of the Dog in the Nightdress by Ross O'Carroll Kelly

Bob Tail Pup by Vernon Stokes and Cynthia Harnett
The Dog it was that Died by H R F Keating
Best Mate (also published as Born to Run??) by Michael Morpurgo
Flush: A Biography of a dog by Virginia Woolf
The Finer Points of Sausage Dogs by Alexander McCall Smith

Also, the most fantastic dog characterisation is done by Marina Lewycka in Two Caravans

R, My Name is Rosie by Barbara Cohen.
Snuffle to the Rescue by Elisabeth Beresford.
A Walk in the Dark by Joyce Stranger.
The Beach Dogs by Colin Dann.
White Ruff by Glenn Balch.

I have many more ...

Queen of the Road: The True Tale of 47 States, 22,000 Miles, 200 Shoes, 2 Cats, 1 Poodle, a Husband, and a Bus with a Will of its own by Doreen Orion
The Shepherd, the Angel, and Walter the Christmas Miracle Dog by Dave Barry
Dogs That Know When Their Owners Are Coming Home by Rupert Sheldrake
Never Have Your Dog Stuffed: And Other Things I've Learned by Alan Alda

and a significant amount of time is spent attempting to NOT eat dog in Lost on Planet China by J. Maarten Troost

Sorry about the broken touchstone.

Good Dog, Carl by Alexandria Day
Harry the Dirty Dog by Gene Zion
Clifford the Big Red Dog by Norman Bridwell
Siberian Husky: A Comprehensive Guide to Owning and Caring for Your Dog by Lorna Winslette
Spot's Birthday Party by Eric Hill

A Good Dog by Jon Katz
Some Dogs Do by Jez Alborough
A Three Dog Life by Abigail Thomas
It's a Dog's Life, Snoopy by Charles Schulz
Dog Day Afternoon by Patrick Mann