Peter AttiaReviews

"Exercise is by far the most potent longevity drug." - I can't agree more with this. So if you're someone who wants to get back on the health track, this book gives some good pointers. If you're already on a routine however, you'll get a confidence boost that you're on the right track.

Author does provide details about cholesterol consequences, glucose and insulin interaction, chemotherapy impact and alcohol effects. I did find a good number of those interesting. The book also advocates to treat sleep as an investment that'll reap benefits even in the long run.

"Focus not only on 'resume virtues' but also on 'eulogy virtues'." - quite thought provoking.

Gets you motivated to care about your health
Elevates your understanding of some functions, like sleep, which increases motivation to care for it
Connects striving for longevity with increasing your health span and living a better life
The way the author explains metabolic functions helped me understand its importance and functions

- Not concise (!)
- Pretends to be more original than it is (Concept of Medecine 2.0 versus 3.0 is helpful, but the author is part of a trend, not its instigator)

Why the 3 stars?
While reading the book, I felt like the author was missing a crucial point. He does devote the last chapter to emotional health with his own personal journey as a therapy patient.
I can only speculate how this book got written: The author got a book contract, started on the path to describing how to hack our biology to live to a hundred, realized along the way, probably after 90% of the book was written, that the whole thing in the end has nothing to do with biohacking, but rather everything to do with having a reason to live to a hundred and this reason is deeply rooted in emotional wellbeing and connectedness with family and community.

I feel like the book is overhyped because at the time I picked it up, it had 4.4 / 5 on Goodreads and it felt to me incomplete in so many ways. Nothing close to a Masterpiece.

This book is *a lot* and will probably take another pass to fully digest all of the information included. I discovered the author when he was a guest on another podcast and was intrigued. I listed to it on audiobook and will likely get a hard copy as well, so I can go back for reference. My biggest take away is that the old adage 'an ounce of prevention is worth a pound of cure' should really be considered when thinking about longevity and how well we feel/how healthy we are. There is not a one size fits all plan for everyone but taking accountability for your own health decisions and using as much of your health data as you can to make your own plan will likely be the best step. It's definitely got me thinking about longevity and healthcare related decisions more.

The author bills the science presented as Medicine 3.0, but at every turn my intuition screamed that what was being presented was at best Medicine 2.1. Not bad if Medicine 3.0 wasn't actually out there, but I feel that it is. You should still read “Outlive”. You should read all such books, popular health or popular medicine, I guess we call it, popular as much for an ability to speak with accessibility to the general populous as having any actual popularity.

We are in an age of embarrassing riches, no more so than with the feast of high quality, well-researched, well-meaning, thoughtful, and nuanced texts presented by such highly qualified individuals. It is to our detriment that we ignore even the scantest evidence where our greatest resource, our health, is concerned. For Peter Attia, I would say that although you can take the doctor out of the training, it's much more difficult to take the training out of the doctor. You really must read it to decide for yourself as I only have my gut instincts to go on. The science is infinitely complex and there is little agreement among the professionals about what it all means. At a certain point we have to trust the deeper parts of our intelligence to take over, synthesizing mountains of data and the various interpretations of those data. Intuition gets short shrift in our society.

Peter Attia seems in the throws of the paradigms he's struggling against, still very much attuned to a mid- to a late 2oth century mindset, a practice still bounded by old understandings despite an ostensibly cheery prognosis overall.

I'm hesitant to give specifics and argue against professional training, but the areas that pinged my radar the highest were his advice on exercise, his reliance on numbers and extreme testing, and his underestimation of the power of fasting. It all seems a bit out of balance to me.

Compare and contrast (for yourself) this book against books like Richard Johnson's “Nature Wants Us to Be Fat” (2022), Daniel Lieberman's “Exercised: Why Something We Never Evolved to Do Is Healthy and Rewarding” (2021), and Steve Hendricks “The Oldest Cure in the World: Adventures in the Art and Science of Fasting” (2022). There are many areas where these books are in agreement with Attia's advice, but worrying in the ways they disagree, sometime sharply. This list of books of course is in no way exhaustive, with new science coming at us every day. We are foolish if we don't at least try to make sense of it all. The stakes are ridiculously high. The price too precious.

Easy to read and a good introduction to the subject. Better than 3 1/2 stars, but not quite up to 4. That Dr. Attia includes his personal story is important and elevates the book overall. For more detail, one should listen to Dr. Attia's podcast, which I find more beneficial overall. Still, I have no regrets over reading this. The book serves an important service in bringing together scientific ideas about longevity and the idea of what it means to live a good life.

Dr. Peter Attia is an oncology surgeon, a data guy, and an extreme athlete with trauma in his past. That all plays into his approach to longevity: lots and lots of screening, monitoring, and "training" for old age as if you were training for a sporting event.

The chapters on exercise and nutrition were fantastic. My favorite quote: "Cardio or weights? Low-carb or plant-based? Olive oil or beef tallow? I don't know. Must we really take sides?" This is NOT a book telling you the One True Secret to long life; it all depends. Some certainties though: Exercise is the best medicine. If your metabolism is not functioning well, make it a priority to get that under control. Screen for everything, screen early, screen often.

Then come chapters on sleep and emotional health. I had really been looking forward to the chapter on sleep, as it's kind of a bugaboo for me. I had grown to feel I could trust his opinions, and I wanted know what he thought about better sleep through pharmaceuticals. He had stated in an early chapter that he had nothing against using medications in general where appropriate, such as statins; so it felt promising that I wouldn't get some knee-jerk anti-medication attitude.

I started reading the chapter one night shortly before bedtime, and didn't get up to any of the advice; just lots of emphatic "Sleep is crucial! Quality, uninterrupted sleep! It's a must! You risk Alzheimer's if you don't get it!" Nice scary nightmares to put a random chronic insomniac to sleep with.

The next night I delved in further. Alas, he's anti-Ambien. Ambien sleep isn't REAL sleep and yadda yadda yadda. However to give him credit, he had positive things to say about trazodone.

The whole sleep chapter was disappointing and did not feel nearly as data-driven as the previous chapters. It just felt like he got it in his head that sleep was very important to health and decided it warranted a whole chapter on a par with exercise & nutrition, but he didn't want to put any work into it.

For the emotional health chapter, I commend him for telling so much of his personal story. This chapter was driven by his own experience and that was OK.

I guess the real overarching theme of the book, though, was that everyone is different, and you must find what works for YOU. Your exercise ability, your own metabolic reactions - these are going to determine the "right" exercise and diet for you. He could have been a LITTLE more understanding about chronic insomnia, though, and respected that different things work (and don't work) for different people. As I said, a bit of a bugaboo for me…

It’s not a terrible book, nor is it any good. if you don’t know anything at all about life extension, this is a good beginners guide for someone of a relatively low IQ, who won’t be bored by the slow pace of the book. if you already know a lot about life extension, this book is not worth wasting your time on.

Lots of valuable research presented in a clear, relatable manner. I appreciated the whole body and mind approach to longevity and making it a life worth living. I went down many rabbit holes while reading this book. I appreciate that there is a lot of extra media supplemental material on his website if you want it. His differentiation between Medicine 2.0 (reactionary at the manifestation of symptoms) and Medicine 3.0 (early detection and prevention) is a key mind shift for everyone. That is the focus of the first section followed by research about The Four Horseman (cancer, heart disease, metabolic issues like diabetes, and neurodegenerative diseases like Alzheimer's). The final part goes into what you can do for prevention. The book's style gives you the TL;DR version (like exercise is key!) and then dives into details if you want them (the need for stabilization and proper form). I'm glad to have found this book. I imagine it will add many years to many lives.

Let me begin my review in the middle of Outlive. The author asks us to list the ten tasks we want to do for the rest of our lives. He calls this list the centenarian decathlon. Here’s the top of the list for me: hike up to Third Burroughs Mountain. It’s 9 miles (14 km) in Mount Rainier National Park with 2500 feet (760 m.) of elevation gain. Why? I’m a hiker, and this is my favorite hike worldwide.

I’ve spent a fair amount of time thinking about how to keep hiking as I get older. I turned 65 in 2022; I would like to keep exploring mountains as long as possible, this is just the book to help me achieve my goal. Let me explain why.

First, Attia starts with the concept of healthspan – how well you live. There’s a tight coupling between healthspan and lifespan. As we age, we have left less of each. One difference is that lifespan is a discrete quantity; one day, you are alive, and the next, you are not. In contrast, our healthspan gradually diminishes over time. The author details three vectors (components) of healthspan: physical, cognitive, and emotional. The good news is that we can usually improve these components and our overall healthspan. How we do so is the core of the book.

The book’s first part outlines our current situation and a target goal. The most important lesson I learned: “Tactics without strategy is the noise before defeat.” a quote from Sun Tzu, an ancient Chinese military strategist. Been there, done that, got the T-shirt. So, how can I do better? The author has a great framework: first, objectives, then strategy, and finally, tactics. The author trained as an engineer, became a physician, and has worked in business consulting; his background shows throughout the book. I touched on objectives in the discussion of the centenarian decathlon; how about strategy?

The second part of Outlive is the science that can help you develop a strategy. There is a chapter on the science of centenarians; I think of this as a boundary condition. What are the factors that helped get someone to their 100th birthday? (I have a hiking friend who still gets out on walks at 101, I want to follow in her footsteps.) Next is a chapter on the details of how nutrition affects longevity. The last four chapters cover the science of how most of us die: metabolic disorders such as diabetes, heart disease, cancer, and neurodegenerative diseases. Understanding these problems will help you develop tactics to mitigate some issues. There are no magic bullets in these chapters; instead, it’s a well-researched survey of what we know as of 2022. Now that we know objectives and strategies, what tactics can we employ?

The final part of Outlive lays out four tactics:

Exercise (cardio, strength, and stability)
Nutrition
Sleep
Emotional health.
At 260 pages, this is the longest part of the book. It was detailed and beneficial to me. Rather than outline each section, let me list some tactics I am adding to my strategy:

Work on stability, specifically starting with a yoga class.
Use a continuous glucose monitor for a few months to optimize my diet.
Ensure I am getting enough protein intake of lysine, leucine, and methionine.
The last chapter on emotional health was the most impactful in the book. Attia opens up to the reader about his emotional health through the lens of a patient rather than a physician. It touched me deeply; I had some trauma in my teen years when my mom died. Fifty years later, I realized I should address some of these issues rather than wall them off.

Outlive is a book I will read several times. The book is challenging; I spent four weeks reading the book.

I made a ton of margin notes and back-of-the-book scrawling. There’s a lot to digest, and there are many references. For example, I want to read the paper Hallmarks of Aging by Carlos López-Otín and colleagues. This book catalyzed some great conversations with my friend Bill about healthspan. I will recommend Outlive to anyone interested in taking action to improve their healthspan.

One closing thought; there’s a missing chapter in the book. I believe social interaction and engagement can improve healthspan’s cognitive and emotional components. My experience is that forty years of marriage have improved my emotional health. I decided to ask ChatGPT: What studies have shown that social interaction and engagement can improve cognitive function and reduce the risk of cognitive decline and dementia in older adults? Here’s the answer:

“There have been several studies that have shown a positive correlation between social interaction and cognitive function in older adults. For example:

The Rush Memory and Aging Project: This study found that older adults who had higher levels of social activity experienced a slower rate of cognitive decline than those who were less socially active.

The MacArthur Study of Successful Aging: This study found that older adults who were more socially engaged were less likely to experience declines in cognitive function over time.

The Women’s Health Initiative Memory Study: This study found that women who reported higher levels of social engagement had a lower risk of developing cognitive impairment than those who were less socially engaged.

Overall, these studies suggest that social interaction and engagement can play an important role in maintaining cognitive function and reducing the risk of cognitive decline and dementia in older adults.”

Really 3.75. To get the full value, worth cross referencing to the many Podcasts that Dr. Attia has contributed to.

This is one of those books that could change your life. I don't know if it will change mine: at 78, I'm a little old to initiate new long behaviours intended to add to my life span. But it may. His message is that exercise, nutrition, sleep, and emotional health can profoundly affect your lifespan, and even more important, your healthspan -- the number of years you remain independent and can do things you love. This is bolstered by extensive description and analysis of the diseases of old age that kill most of us, and by extensive explanation and description of what you can do about it. His prescriptions for action are daunting, demanding lots of time and lots of discipline. But I think they will actually change my behavior. One reason that this book is so powerful is that it is so personal, which is one reason why it is such a fascinating read. I can't recommend it too highly.

NF